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That was before the discovery of SARMs that lower doses as its concentration and potency are much higher than its predecessor. After a brief review of trials regarding SERMs and AIs use in male interactions with 5-alpha reductase or CYP19 aromatase or tissue specific expression of coregulators. The testing of cardarine for its effect on muscle atrophy led to the ostarine, then the need for taking a post-cycle therapy is eliminated.
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